Omega Phi Chi was established on November 9, 1988, at Rutgers University–New Brunswick by eight women of Asian, African American, and Latina descent.

They came together to found a multicultural sorority; a different type of organization that would not be categorized by ethnicity, creed, or culture.

The founding mothers of Omega Phi Chi Multicultural Sorority Inc. are: The purpose of Omega Phi Chi is to create a unity among all women and promote ethnic diversity by integrating women of all boundaries and cultures.

Since its inception, the sorority has grown to include over 95 different nationalities and has started 24 chapters in New Jersey, New York, Florida, Arizona, Texas, Indiana, and California.

[1] The core value of Omega Phi Chi is "Academic Excellence and Involvement in Community Affairs".