Theta Nu Xi was founded during a time when cultural Greek organizations began to proliferate on campuses across the United States.

The founders were Geeta Nadia Kapur, Natalie Nicole Barker, Peggy Virginia Long, Melissa Jo Murchison-Blake, Brenda Imade Eribo, Katherine Ellen Stanley, and Janelle Kalia Poe[1] In the early days of its existence, the sorority met resistance from its campus of founding.

Despite such resistance, the national founders' continued efforts set the stage for Theta Nu Xi's presence in the Greek, non-Greek, and surrounding communities.

The University of North Carolina at Chapel Hill officially recognized Theta Nu Xi Multicultural Sorority as the Alpha chapter on April 11, 1997.

The earliest members of Theta Nu Xi addressed an immediate need to develop an official process of expansion that would support new entities as well as serving the interests of the sorority.

During the same meeting, Soror Amanda Greene, representing the Alpha chapter, submitted a resolution to create a committee to examine the role of alumnae and professional membership.

Founding Monarchs Melissa Murchison-Blake and Janelle Poe, along with Sorors Holly Woodard and Rebecca Treherne, officially chartered the first GAP chapter on April 11, 2002.

The objectives of the sorority are to incorporate separate cultures into one life, to build self-esteem through sisterhood, to participate in service activities, especially those concerning diversity in the community, to encourage academic excellence and overall self-improvement, and to promote unity among Greek organizations.