Ōmura Line (大村線, Ōmura-sen) is a railway line in Nagasaki Prefecture, Japan, operated by the Kyushu Railway Company (JR Kyushu).

It connects Haiki Station in Sasebo to Isahaya Station in Isahaya.

The Kyushu Railway Co. opened the entire line in 1898 as part of the original Nagasaki Main Line.

With the opening of the Hizen Yamaguchi - Isahaya section of the Nagasaki Main Line in 1934, the line was renamed the Omura Line.

In 1992 the Haiki - Huis Ten Bosch section was electrified at 20 kV AC.