OnPoint NYC is a New York City nonprofit that operates two privately run safe injection sites (also known as Overdose Prevention Centers) in East Harlem and Washington Heights.

[2] OnPoint was created in 2021 from the merger of two existing groups, New York Harm Reduction Educators and Washington Heights Corner Project.

[4][6] Under President Joe Biden, the United States Department of Justice has taken a hands-off approach to safe injection sites,[7] although possession of opioids without a prescription remains illegal.

Al Sharpton and Adriano Espaillat) have criticized the Harlem site, viewing it as part of an oversaturation of shelters and addiction treatment facilities in the neighborhood.

[9] In 2023 NYU Langone Health and Brown University announced that OnPoint would be included in the first federally-funded study to evaluate the effectiveness of OPCs.