The film stars Irene Rich, Raymond Hackett, H. B. Warner, Wheeler Oakman, Marion Shilling and Ilka Chase.

"[5] Putting a son through college, Julianne, owner of a Fifth Avenue dress shop in New York City, is persuaded to supplement her income by providing loans to struggling showgirls.

One contemporary review provided both a detailed synopsis and documentation of the screenplay's source: "Irene Rich is seen as a brilliant Fifth Avenue modiste who tells the lovely ladies she meets to wear their brains on their backs.

The story is a Fox movietone production of Rita Weiman’s intriguing character analysis which appeared earlier this season in magazine form.

‘Wear Your Brains on Your Back’ is adapted early in her career as an enticement for girls of the chorus, and actresses, to pay more than they can afford for her fashionable creations.