Pegaspargase, sold under the brand name Oncaspar, is a medication used in the treatment of acute lymphoblastic leukemia (ALL).

[6] Known side effects include allergic reactions, coagulopathy, high blood sugar, affecting liver function, pancreas inflammation, and blood clots in the brain.

[7] Therefore, caution should be observed and pegaspargase should only be used during pregnancy when the benefits outweigh the possible risks.

Pegaspargase is a modified version of the enzyme asparaginase which has undergone PEGylation.

[8][6] It works by breaking down the amino acid asparagine that are circulating in the bloodstream.