Players take the role of a man who wakes up from a drunken one-night stand beside a stranger and must piece together the events of the previous night.

Based on the player's actions and dialogue choices, they can unlock many different endings, ranging from being angrily kicked out to the possibility of friendship.

[1] One Night Stand was developed using the free Ren'Py visual novel software, and Blundell credited its community with supporting her.

Comparing it to other games that feature physical relationships, Ahmed cited it as an example of using dialogue to tell a story rather than as a gameplay mechanic used to reach a desired conclusion.

[10] Kill Screen wrote that the initial mystery – what happened the previous night – becomes less interesting than learning about the woman and trying to find a happy ending.