One a Minute is a 1921 American comedy silent film directed by Jack Nelson and written by Frederick J. Jackson and Joseph F. Poland.

The film stars Douglas MacLean, Marian De Beck, Victor Potel, Frances Raymond, Andrew Robson, and Graham Pettie.

[1][2] As described in a film magazine,[3] college graduate Jimmy Knight (MacLean) returns to the small town of his birth where he takes over his deceased father's drug store and combats a trust's drug store that has eclipsed the older institution in the public's favor.

He falls in love with Miriam (De Beck), daughter of Silas P. Rogers (Robson), the magnate controlling the trust, and fights against elimination to win her plaudits.

As a desperate means of fighting the competition he places on sale a harmless concoction he calls "Knight's 99", representing it as his father's secret formula that cures all disease.