Highway 599 is a long and isolated road in Northwestern Ontario that travels generally southwest–northeast through the dense forests, lakes and hills of Thunder Bay and Kenora District.

Highway 599 meanders around numerous lakes and through uninhabited forests, not encountering any habitation for nearly 50 km (31 mi).

It then enters the small community of Silver Dollar, where Highway 642 branches west to Sioux Lookout.

[3] North of Silver Dollar, Highway 599 re-enters the wilderness for 67 km (42 mi), although several outfitters are located along the otherwise barren stretch.

Approximately 9 km (6 mi) north of Savant Lake, it encounters Highway 516, which branches west towards Sioux Lookout.

It links up with winter roads that travel to isolated communities even farther north, terminating at the northern shore of Windigo Lake.

[8] In 1958, construction began to connect the route with Highway 17 near Ignace, working south from Savant Lake.