It stars Akkineni Nagarjuna, Karthi (in his Telugu debut) and Tamannaah Bhatia while Prakash Raj, Ali, Vivek, Jayasudha, Kalpana and Tanikella Bharani playing supporting roles.

The narrative focuses on the lives of Vikramaditya, a quadriplegic billionaire, and Seenu, his ex-convict caretaker, highlighting their realisation of the importance of life and relationships over money and disability.

Principal photography took place from March 2015 to February 2016 in locations including Chennai, Hyderabad, Paris, Belgrade and Novi Sad.

Both films garnered critical acclaim for the performances of the lead actors, their cinematography and Vamshi Paidipally's direction in adapting the original story.

He defends his decision to Prasad, his longtime friend and legal advisor, saying that Seenu is the right person for the time being since he is the only one who doesn't pity him.

Vikramaditya, recognising Seenu's need to support his family by being present, releases him from his obligations and suggests that he may not want to push a wheelchair all his life.

Seenu becomes a cab driver and leads a responsible life, this time with his family's love and acceptance, but Vikramaditya becomes unhappy and becomes a recluse.

Karan Johar and Guneet Monga acquired the Indian remake rights to Éric Toledano and Olivier Nakache's French comedy drama film, The Intouchables (2011) in May 2014.

[4] Johar and Monga later authorised PVP Cinema to remake the film in regional languages, postponing their previous plans.

[8] Rama Rao Jr. left the project due to scheduling conflicts with Nannaku Prematho (2016),[9] and was replaced by Karthi in October 2014.

Rajeev Kamineni of PVP Cinema told The Hindu that Karthi was cast to combine actors who were audience favourites and had not collaborated before.

[27] After Haasan left the film, PVP Cinema claimed that her scheduled dates (from 10 December 2014 to 8 April 2015) were assigned for her convenience and the actress was civilly and criminally liable.

[29] Haasan withdrew her defamation suit in April 2015 after R. Sarathkumar and Kalaipuli S. Thanu intervened, and the court dismissed PVP Cinema's case.

[30] Prakash Raj, Ali, Vivek, and Tanikella Bharani were cast in key supporting roles,[14][15] with Jayasudha and Nikkita Anil playing Karthi's mother and sister.

[35] Gabriella Demetriades was cast in August 2015 after auditioning with five other international models in Hyderabad,[36] and the film was her South Indian acting debut.

[42] A month-long European shooting schedule began in July in Belgrade and Novi Sad, and Oopiri was the first South Indian film made there.

It was shot near the Eiffel Tower, which Paidipally called the "obvious choice to show the moment of triumph" in Vikramaditya's life.

[47] Tamannaah found her dialogue simple and realistic and delivered her own lines in Oopiri, the first Telugu film to include her voice.

The Times of India gave Oopiri's soundtrack four stars, calling it a "winner on all counts" and Sunder is "increasingly becoming a force to be reckon with in [Telugu cinema]".

[52] Karthik Srinivasan, writing for The Hindu, praised Sunder's usage of solo violin pieces and chorus hooks in Thozha's "Pudhidhaa" ("Oka Life" in Oopiri).

[59] Baradwaj Rangan, writing for The Hindu, found Thozha enjoyable despite its lack of narrative finesse and called it a light, pleasant film comparable to Bangalore Days (2014).

She wrote that Nagarjuna's portrayal of Vikramaditya was "age-defying, graceful and restrained" and praised the rest of the cast, Vinod's cinematography, and Sunder's score.

[61] Pranita Jonnalagedda of The Times of India gave Oopiri four stars out of five, writing that it "sets a benchmark for adaptations in Telugu cinema" and "paves the way for more exciting genres".

[62] According to Anupama Subramaniam of Deccan Chronicle, Thozha had an "alluring story" supported by "extraordinary performances, sound technical departments and rich production values".

[63][64] Writing for India Today, Kirubhakar Purushothaman also gave the film 3.5 stars out of five, calling it a decent remake which "retains the soul of the original" with "the right cast and the perfect team".

[67] Sify also gave the film three stars out of five and called it a "breezy feel good ride"; its reviewer praised its performances and visuals, but criticised its length.

[70] The film further increased its total gross to ₹27 crore in its first week and earned $1 million in the overseas market during that time, according to Firstpost.

[71] Inspired by the film, paraplegic television personality Sujatha Barla established the Challengers on Wheels-Celebrating Life community for physically disabled people in April 2016.

[76] Judge G. Neelima took 60 underprivileged female students in Balasadan, Warangal to a special screening of Oopiri on the eve of Ugadi.