Opelousas Catholic School is a private, Catholic school in Opelousas, Louisiana.

Located in the Roman Catholic Diocese of Lafayette, the school offers education from pre-kindergarten 3/4 through 12th grade.

Holy Ghost High School, a segregated African American Catholic school was closed in 1971, and merged along with Academy of the Immaculate Conception (AIC), a segregated White Catholic school, into Opelousas Catholic School in September 1971.

[2][3][4] Opelousas Catholic athletics competes in the LHSAA.

This Louisiana school-related article is a stub.