[6] Much of the film was inspired by the artist and musician Genesis P-Orridge,[7] who served as creative consultant on the film and is included in a post screening dialog with Jake Yuzna at New Museum[8] available as a DVD bonus feature on the North American release.

The Detroit-based music duo Adult created an original score for the film.

When the young hermaphrodite Cynthia (Gaea Gaddy) meets Gen (Tempest Crane) and Jay (Jendeen Forberg), a couple recovering from plastic surgery, she learns of Pandrogyny, in which two people merge their facial features in order to reflect their evolution from separate identities into one unified entity.

Inspired by this, Cynthia abandons her husband and suburban life to embark on a road trip with Gen through the remnants of 20th century America.

Not science fiction, but American reality, OPEN brings together a cast of real hermaphroditic, pandrogynous, and transpeople to create a revealing look at the pioneers of the new human experience, and the emerging possibilities for humanity at the dawn of a new millennium.