[citation needed] He attended Whitney M. Young Magnet High School and went on to Southern Illinois University Carbondale where he majored in psychology.

[citation needed] In 2010, Open Mike Eagle released his first solo album, Unapologetic Art Rap, on Mush Records.

[17] In that year, he co-authored and participated in a study conducted by the National Institutes of Health that observed the locations of increased brain activity during freestyle rapping.

[20] In 2017, he released Brick Body Kids Still Daydream, a concept album about the Robert Taylor Homes, a public housing project in Chicago, Illinois.

[24] In June 2015, Eagle along with John Moe, launched "Conversation Parade", a podcast in which the two discuss the Cartoon Network animated television series Adventure Time.

The podcast has featured guests like Jeremy Shada, John DiMaggio, Hynden Walch, Adam Muto, Kent Osborne, Niki Yang, Olivia Olson, Jesse Moynihan, Jessica DiCicco, Elizabeth Ito, and Neko Case.

[26] Mike Eagle also co-hosts the pro wrestling podcast Tights and Fights with Hal Lublin and Danielle Radford on the Maximum Fun Network.

[30] On April 18, 2017, Comedy Central announced they were greenlighting The New Negroes, a stand-up and musical series co-hosted by Open Mike Eagle and Baron Vaughn.