[7] Ophelia Crossland started her fashion career in 2004 and has made clothes for prominent personalities in Ghana including the former Speaker of Parliament, Joyce Bamford-Addo, the Chief Justice Georgina Theodora Woods,[8] former First Lady Nana Konadu Agyeman-Rawlings, Gifty Anti, and Joselyn Dumas.

She was also credited with the making of the gown Ghana's Miss Universe representative wore on the night of the finals in Thailand.

[11] In September 2019, Crossland was announced as Africa and Ghana's sole representative at the Global Qipao Invitational Exhibition at the China National Silk Museum Hangzhou, Zhejiang Province.

[13][14] Vogue Italia also featured her charity work with Ghanaian head porters popularly known as Kayayei in fashion.

[15][16] She is married to Ghanaian Broadcaster and fashion designer, Kofi Okyere Darko (KOD) and they have two daughters.