Ophidiophobia

[3] In The Handbook of the Emotions (1993), psychologist Arne Öhman studied pairing an unconditioned stimulus with evolutionarily-relevant fear-response neutral stimuli (snakes and spiders) versus evolutionarily-irrelevant fear-response neutral stimuli (mushrooms, flowers, physical representation of polyhedra, firearms, and electrical outlets) on human subjects and found that ophidiophobia and arachnophobia required only one pairing to develop a conditioned response while mycophobia, anthophobia, phobias of physical representations of polyhedra, firearms, and electrical outlets required multiple pairings and went extinct without continued conditioning while the conditioned ophidiophobia and arachnophobia were permanent.

[5] Psychologist Paul Ekman cites this anecdote by Charles Darwin in The Expression of the Emotions in Man and Animals (1872) in connection with Öhman's research: I put my face close to the thick glass-plate in front of a puff-adder in the Zoological Gardens, with the firm determination of not starting back if the snake struck at me; but, as soon as the blow was struck, my resolution went for nothing, and I jumped a yard or two backwards with astonishing rapidity.

[6][7]Psychiatrist Randolph M. Nesse notes that while conditioned fear responses to evolutionarily novel dangers such as electrical outlets is possible, the conditioning is slower because such cues have no prewired connection to fear, and that despite the emphasis on the risks of speeding and drunk driving in driver's education, it does not provide reliable protection against traffic collisions and that nearly one-quarter of all deaths in 2014 of people aged 15 to 24 in the United States were in traffic collisions.

[8] Also, Nesse, psychiatrist Isaac Marks, and evolutionary biologist George C. Williams wrote that people with systematically deficient responses to adaptive phobias (e.g. ophidiophobia, arachnophobia, basophobia) are more temperamentally careless and more likely to receive unintentional injuries that are potentially fatal and have proposed that such deficient phobia should be classified as "hypophobia" due to its selfish genetic consequences.

[9][10][11][12] A 2001 study at the Karolinska Institute in Sweden suggested that mammals may have an innate negative reaction to snakes (and spiders), which was vital for their survival as it allowed such threats to be identified immediately.

A man, tied to a cliff, cowers at a snake menacing at him from inches away.
The Punishment of Loki by J. Doyle Penrose