Opilio Rossi (14 May 1910 – 9 February 2004) was a cardinal of the Roman Catholic Church and president of the Pontifical Council for the Laity.

He was educated at the Collegio Alberoni in Piacenza and later the Pontifical Roman Athenaeum "S. Apollinare" in Rome where he earned a doctorate in canon law with a thesis on St.

He was created Cardinal Deacon of S. Maria Liberatrice a Monte Testaccio by Pope Paul VI in the consistory of 24 May 1976.

He resigned the presidency of the Pontifical Council for the Laity on 8 April 1984 and was succeeded by Cardinal Eduardo Pironio.

He is buried at the chapel of Madonna di Lourdes, parish church of Scopolo, diocese of Piacenza-Bobbio, where he used to pray as a child.