Carole Horst of Variety wrote of the series, "Clever concept, sleek production values, a nice cast and thoughtful writing (for a teen show) add up to the enjoyable Opposite Sex".

[4] Barry Garron of The Hollywood Reporter described Opposite Sex as a "far-fetched, overly earnest teen-oriented show" that "never manages to overcome its contrived premise and establish real emotional connections.

"[5] He went on to say that "My So-Called Life and Freaks & Geeks have raised the bar for teen drama by providing keen insight into the awkwardness of adolescence" and that while not on the same level this series is "not nearly as cartoonish" as Saved by the Bell.

[5] Joel Brown, a New York Times syndicated columnist published in The Spokesman-Review found that "Ventimiglia conveys Jed's frustration well" but that "bad TV cliches overwhelm this show's mild promise.

"[6] The Modesto Bee's TV critic, Kevin McDonough, describes the series as "hardly the worst teen show of the year" and stated that "it lacks the soft-core exploitation that permeates Young Americans.