Oprah Winfrey got her roots in 1988 when Harpo Productions had to acquire her eponymous talk show from ABC O&O WLS-TV in Chicago, and automatically renewed its deal with King World Productions, who held minority interest, which was set to expire in 1991.

[9] The company was previously based in Chicago, with Harpo Studios situated in the West Loop neighborhood.

[11] That documentary series became known as The Me You Can't See, which Winfrey co-hosts with Prince Harry, Duke of Sussex.

[14] In July 2020, it was announced that O, The Oprah Magazine will end its regular print edition after the December 2020 issue.

"[17] Harpo Studios was the home of The Oprah Winfrey Show from January 15, 1990. located in the West Loop neighborhood of Chicago.

The land where the production studio stood once housed the 2nd Regiment Armory that was used as a makeshift morgue for victims of the capsizing of the steamer SS Eastland.

[21] Previously, Harpo Films had a deal with ABC, which included production of Oprah Winfrey Presents: Mitch Albom's For One More Day.

[21] In February 2013, Harpo Films was shut down, citing that "the demand for long-form projects, especially on the broadcast side, has dried out.

Regular presenters included specialists from a variety of fields, including Dr. Maya Angelou, Marianne Williamson, Dr. Mehmet Oz, Bob Greene, Nate Berkus, Jean Chatzky, Gayle King, Rabbi Shmuley Boteach, and Holly Robinson Peete and Rodney Peete.