She made two complete voyages as a slave ship in the triangular trade in enslaved people.

[1] 1st voyage transporting enslaved people (1790–1791): Captain Andrew Irving sailed from Liverpool on 27 November 1790.

[a] He started acquiring captives on 7 February 1791, first at some unknown port in the Bight of Benin, and then at Lagos, Onim.

[2] 2nd voyage transporting enslaved people (1792–1793): Captain William Carrol sailed from Liverpool on 25 February 1792.

[5] Orange Grove arrived at Kingston, Jamaica on 28 December with 236 captives.