The Oratorio di San Mercurio is a Baroque chapel or prayer room located adjacent to the former Benedictine convent and church of San Giovanni degli Eremiti, in the quarter of the Albergaria, within the historic centre of Palermo, region of Sicily, Italy.

The oratory was founded in 1557 by an aristocratic confraternity known as the Compagnia di Santa Maria della Consolazione.

The order was affiliated with a number of churches in Palermo, including the Carmine Maggiore a few blocks away.

The oratory hall is preceded by an elegant staircase built in 1719 and an antiroom with maiolica pavement and a fresco depicting Jesus visits the jailed St Mercurius.

The maiolica pavement of the main hall was completed in 1714-1715 by Sebastiano Gurrello and Maurizio Vagolotta, based on a design by the architect-priest Giulio Di Pasquale.