The Oratory of St. Thomas Aquinas is a late-Renaissance-style, Roman Catholic prayer hall located on Via della Pergola in Florence, region of Tuscany, Italy.

The simple facade stands across the street from the Hospital of Santa Maria Nuova; it was initially the site of the Congregation of the Noble Contemplatives (Congregazione dei Contemplanti dei Nobili), founded by a Dominican friar, named fra Santi di Cini, from the Convent of San Marco.

In 1568, the painter Santi di Tito, designed the oratory for the confraternity, and it was dedicated it to St Thomas Aquinas.

The altar has walls decorated in elaborate and fine scagiole by Carlo Ghibertoni.

The ceiling was decorated in 1710 with quadratura by Rinaldo Botti, and depicts the Glory of St Thomas painted by Camillo Sagrestani and Ranieri del Pace.