While in Pendleton, it overlaps U.S. Route 30 for a short distance, before leaving the city heading in a north-northeasterly direction, along the base of the Blue Mountains, passing near the communities of Havana and Blakeley and through the cities of Adams and Athena.

Approximately 30 miles (48 km) north of Pendleton, OR 11 passes through the city of Milton-Freewater.

Just north of Milton-Freewater, OR 11 ends at the Washington state line.

While only 34 miles (55 km) today, OR 11 once ran from the Washington to the California borders.

Milepoints are as reported by ODOT and do not necessarily reflect current mileage.