It is 9.79 miles (15.76 km) long and runs north–south, entirely within Umatilla County.

OR 335 was established in 2003 as part of Oregon's project to assign route numbers to highways that previously were not assigned, and, as of October 2020, was unsigned.

OR 335 ends at an intersection with OR 11 4.24 miles (6.82 km) south of Midway near a former railroad station.

[3] It ran from the Oregon-Washington Highway (OR 11) along the existing Market Road No.

[3] A nearby quarry provided basalt for the Oregon State Highway Department's (later the Oregon Department of Transportation (ODOT)) road-building projects.