The southern terminus of Oregon Route 141 is at Exit 286 on Interstate 5 in northern Wilsonville.

From there, the highway runs north along Boones Ferry Road, through the city of Tualatin and past the community of Durham.

It then heads north on Hall for several miles, crossing OR 99W in Tigard, and eventually ending at an intersection with OR 210 (Scholls Ferry Road) in the community of Progress (though the intersection is technically within the city of Beaverton).

This route, along with a further extension north into Beaverton on Hall Boulevard, and a further extension south into Woodburn via Boones Ferry Road, was the original route of OR 217, before the current freeway alignment was constructed in 1972.

Prior to the opening of the current OR 217 freeway in the 1970s, the entire route of OR 141 was part of the original OR 217 that connected OR 8 in Beaverton to US 99E in Aurora.