After passing a collection of shopping malls and motel chains around the Woodburn exit, OR 219 starts winding its way through the Marion County countryside, heading in a northwesterly direction.

In Newberg, the route intersects OR 18 (the Newberg-Dundee Bypass) before it joins (and overlaps) OR 99W along the Pacific Highway West No.

Immediately north of Newberg, the route enters a steep, narrow, twisty section as it climbs out of the Willamette Valley into the hills overlooking the town.

Keeping on OR 219, one then heads in a general northwesterly direction, running parallel to the western bank of the Tualatin River.

About five miles (8 km) after that, OR 219 enters the city of Hillsboro as it crosses the Tualatin River and passes by Jackson Bottom Wetlands Preserve.

[3] Entering downtown Hillsboro, OR 219 becomes South 1st Street before ending at the intersection with Oregon Route 8, the Tualatin Valley Highway.