OR 22/OR 99E then leave downtown via Pringle Parkway, skirting the southern edge of the Willamette University campus, then, via a pair of ramps, interchange with Mission Street.

This interchange marks the end of OR 99E Business; OR 22 continues to the east along North Santiam Highway.

[3] Local opposition cancelled the freeway in 1976 and the state government requested its withdrawal from the Interstate System in 1977.

The original alignment of OR 99E through Salem came from the south off I-5 onto Commercial Street and left to the north on Portland Road to cross I-5.

The exact location and alignment of this proposed new bridge and its connecting routes is presently under study, but generally, the routes being considered would connect to OR 99E Business at or near the southern end of Salem Parkway on the river's eastern shore, and provide access to both OR 22 and OR 221 on the western side.