It is 27.60 miles (44.42 km) long and runs north–south, entirely within Curry County.

[1] On February 26, 2019, the Hooskanadan Slide took out a nearly quarter-mile long section of U.S. 101, causing the road to slough away in places and buckle in others.

ODOT closed the highway at milepost 344; OR 255 serves as a detour for the time being.

Trucks attempting to travel between Brookings (or points south) and Pistol River (or points north) can find a viable detour via US 199 in Crescent City to Interstate 5 in Grants Pass, then heading north to Winston and heading west on OR 42 back to U.S. 101.

Milepoints are as reported by ODOT and do not necessarily reflect current mileage.