Oregon Route 351 (OR 351) is an Oregon state highway running from Joseph to Wallowa Lake State Park.

It is 6.94 miles (11.17 km) long and runs north–south, entirely within Wallowa County.

OR 351 was established in 2003 as part of Oregon's project to assign route numbers to highways that previously were not assigned, and, as of January 2024, was unsigned.

OR 351 begins at an intersection with OR 82 and OR 350 in Joseph and heads south past Wallowa Lake through Wallowa Lake State Park, ending 0.04 miles (0.064 km) past the southern boundary of the park.

OR 351 was assigned to the Joseph-Wallowa Lake Highway in 2003.