The route continues east after that, passing through the communities of Scottsburg and Green Acres.

In the city of Elkton, the highway intersects with Oregon Route 138, which continues to follow the Umpqua River, heading south.

The highway continues east through the mountains of southwestern Oregon, eventually reaching the community of Drain.

OR 99 continues north, sharing an alignment with I-5 (diverting from it once again when it the highway reaches the city of Cottage Grove).

For the majority of its length, OR 38 is a two-lane undivided highway, with occasional passing lanes.