The route begins at South A Street which also carries eastbound OR 126 Business.

One block north, the route intersects Main Street, OR 126 Business westbound.

OR 528 ends at an interchange with OR 126 though the Pioneer Parkway continues north as a municipally-maintained street.

The route also has an additional lane in the center of the right of way each way dedicated to the Emerald Express Gateway Line for bus rapid transit.

South of F Street, the bus lanes can also be used by cars to make left turns.