The story features Nick Fury and the Avengers investigating the murder of Uatu the Watcher, only to suffer trauma from what they see in his eyes.

Writer Jason Aaron and Mike Deodato conceived the "Original Sin" storyline as one in which different heroes worked together in different investigations to find out who murdered Uatu the Watcher.

On Earth, Captain America, Wolverine, Black Widow, and Nick Fury are contacted by a panicked Thor.

The group journeys to the Moon, where they discover Uatu dead, killed by gunshots to the head, his eyes missing.

[3] Fury warns that given the few people who knew of Uatu's existence and had the ability to murder him, his killer could be one of their allies, but Captain America insists on discovering the truth.

Three teams are formed to investigate the leads: Emma Frost, Scott Lang and Black Panther go to the center of the Earth; Moon Knight, Winter Soldier, and Gamora head into deep space; and Doctor Strange and Punisher travel to another dimension.

Moon Knight, Gamora and Winter Soldier find the murdered hulk of a sentient planetoid, but their actions are observed by Panther's shadowy source, who tells a subordinate that they will need more gamma bullets.

Panther traces the signal his source used to contact him to a satellite in orbit around the Earth, where Fury's corpse is found, and where all three teams converge to confront one another.

[6] Fury tells the heroes an account from 1958, when as a member of U.S. Army Intelligence, he fought off an invasion of alien Tribellians in Kansas.

It was in that battle that he witnessed the heroic death of Woodrow McCord, who defeated the aliens before being fatally injured.

Over the decades, Fury secretly fought superhuman threats, from aliens to subterranean monsters and extra-dimensional beings, as a side job to his work with the Army, the CIA, and later, S.H.I.E.L.D., one that no one at either organization ever knew about.

Hoping to rehabilitate his reputation after it was damaged during the period when his body was occupied by Doctor Octopus' mind, he goes to assist in their battle with the Mindless Ones.

When he arrives there, the Orb activates the gouged-out eye of Uatu, causing everyone present to instantly attain heretofore hidden knowledge about their lives, Spider-Man sees that the spider whose bite granted him his superhuman abilities had also bitten a girl named Cindy Moon.

He recalls Madame Web's prior statement to him (during the 2011 "Spider-Island" storyline) that someone would take his place if he chose not to continue being Spider-Man.

[11] The crime boss Eel is confronted by Black Cat and Electro, who inform him that they are taking over his criminal enterprise.

Black Cat then arrives at a meeting of criminal bosses and tells Mister Negative that she wants in on "the big leagues".

During the battle, Spider-Man is incapacitated, and Black Cat prepares to unmask him in front of the running TV cameras.

Although Electro accepts being depowered when his uncontrollable abilities prove dangerous even to himself, Black Cat continues her vendetta against Spider-Man regardless of who is behind the mask.

[13] When confronted by the eye of the murdered Uatu, Bruce Banner experiences some of Tony Stark's memories of their first meeting before they became the Hulk or Iron Man.

[14] Experiencing the same vision, Stark tries to deny that he could have done such a thing, but his research only confirms that he repressed the memory of making the modifications while Banner uses a modified Extremis virus to transform into the Hulk while retaining his intellect.

[15] Attempting to escape the Hulk, Iron Man flees to his new city of Troy, incredulous at what their vision revealed.

[19] As Thor and Angela battle, the Queen of Angels tells young Loki another shocking secret about Odin.

During the times before recorded history, the Angels were protectors of ancient mankind from rogue Asgardians who hunted man for sport.

[20] While Loki led an Angel fleet to Asgard, under the false pretense to help them destroy it, Thor escaped captivity and, once again, engaged Angela in combat.

The man tells Lineage of how, in the past, Black Bolt fought a Kree force trying to use the Terrigan Mists, wiping them out.

Bury the Lead: The eye of the murdered Uatu revealed that J. Jonah Jameson had fired a former Daily Bugle employee for viewing an embarrassing article that he wrote in which he praised Spider-Man in his early days of being a wrestler.

[24] A Wall Street wheeler-dealer learns a secret about Doctor Doom and plans to use this to blackmail his way to wealth, boasting about it to a friend who urges him not to do this.

Unable to handle the loss of his best friend, Fury used a special LMD to rebuild him, occasionally killed off but rebuilt.

The Dugan LMD then puts his pistol to his head, asks Fury not to bring him back, and fatally shoots himself.