The series focuses on the Oglala Lakota inhabitants of the fictional Prairie Rose Indian Reservation in modern-day South Dakota as they grapple with organized crime, rampant poverty, drug addiction and alcoholism, local politics and the preservation of their cultural identity.

[1] Jason Aaron has said the plot of the comic is partly inspired by Leonard Peltier, a Native American activist who was arrested for the murder of two FBI agents in a reservation shootout in 1975.

After raiding a number of meth labs to clean up the Reservations' public image before the opening of the casino, it would appear Bad Horse has cemented his reputation as a ruthless and effective Tribal officer.

Dashiell's initial doubts about the undercover operation are exacerbated when he and his partner, Officer Falls Down, are sent by Red Crow to raid a meth house without backup.

Declaring Dashiell an arrogant, reckless, stubborn, out-of-control "borderline sociopath with deep-seated anger", Nitz remains convinced that he's perfect for the undercover assignment.

Dino's homelife is shown, along with his desire to leave the reservation; while cleaning up Diesel's vandalism at the casino, he gains the sympathy of Red Crow, who gives him money.

In the single-issue storyline "Dreaming Himself into the Real World", Dash, an FBI agent, confronts his fears of being discovered while exploring his hidden Indian heritage.

Through a transformative dream, guided by his deceased mother, Dash journeys through significant moments in Lakota history, inspiring him to embrace his cultural identity and face his fears.

Issues #13 through #17: after raiding a meth house, Dash assumes control of a homicide investigation after discovering Diesel strangled an addict as her children slept in the next room.

Red Crow, filled with grief and anger over Gina's murder, finds his affairs complicated with the arrival of Mr. Brass, a ruthless enforcer sent by gang leader Johnny Tongue to purge the reservation of perceived threats to the casino.

Dash is informed of his mother's death and chooses instead to focus on the deceased addict's homicide case, in the process playing surrogate father to her eldest teenage son Shelton, taking him camping and teaching him to shoot.

Dash arrives at a trailer park to find Shelton dead from gunshot wounds, his killer Diesel already in Sheriff Karnow's custody.

Realizing he is the only person interested in discovering Gina Bad Horse's murderer, Red Crow approaches Officer Falls Down and asks him to conduct an independent investigation.

Burdened by Shelton's death, Dash instigates a bar fight and drunkenly stumbles down the road, arriving at his deceased mother's home.

Dino Poor Bear, finally able to afford the necessary automotive parts, takes his partially restored Camaro on the highway and is promptly pulled over by the corrupt Reservation Police, who task him with delivering a package over state lines to a meth dealer.

This task proves challenging to Red Crow, prompting him to abstain from his typical criminal dealings while also forcing him to remember his turbulent past with Gina and the sins and evils he's perpetrated on the journey to opening his casino.

Mr. Brass, classifying the Reservation occupants as inferior animals, treats them as such, routinely torturing or murdering Red Crow's employees for dealing drugs, weapons, and various other minor crimes whose prosecution could lead to an investigation into the casino.

One night, Brass and his bodyguards follow a pair of corrupt Reservation police into a bar, killing them and cornering their delivery boy, Dino Poor Bear, gouging out his eye to punish him for his crimes.

Bemoaning his lack of luck and dire financial straits, he recognizes Dashiel Bad Horse as the FBI Agent who busted him years ago in Alabama.

On their ride back to Prairie Rose, Catcher prophesizes Bad Horse as a Lakota warrior meant to save the reservation, and offers his assistance.

Unbeknownst to Red Crow at the time is Ben White Elk, a local dealer in the next cell who witnessed the shooting, a loose end Shunka vows to fix later.

In the restroom, White Elk recognizes Bad Horse as one of his customers, and threatens to tell Red Crow about his heroin habit if he doesn't help him escape.

It also shows Carol contemplating suicide before Granny Poor Bear tells her that having a baby is a good thing and also convinces her to join a rehabilitation clinic and move in with her.

The fifteen years in between were spent on contact sports, learning Jeet Kune Do and Boxing, and serving with the U.S. Army in the Kosovo War before becoming an FBI agent.

John Rayfield Bustill, a bullish Lakota elder in his fifties, Red Crow's professional demeanor conceals a cold determination to elevate his Reservation beyond their dire surroundings, no matter the cost.

Red Crow has unresolved romantic feelings for Gina Bad Horse, with whom he shares a history during their times as militant Native American rights activists.

"Catcher" Pendergrass, born 1952 in West Chester, Pennsylvania, was a man of Red Crow's generation; he was present when the federal agents died, but he has never said a word about his role in the murders.

In a two-part arc focusing on Shunka, it is revealed that he is a closeted homosexual who has to deal with widespread homophobia in his line of work, including from Red Crow himself.

Phuong Yii Brass: A member of the Hmong's criminal organization sent by Johnny Tongue to ensure the security of his investment, the Crazy Horse Casino.

Wade is shown to have miraculously survived numerous deadly scrapes in Vietnam, and for that reason he was recruited by two of his war colleagues to be the FBI's mole in the Dog Soldiers.