The Orion Clemens House, also known as Mark Twain's House, is a two-story Late Victorian house located at 502 N. Division St. in Carson City, the capital of the U.S. state of Nevada.

It was listed on the National Register of Historic Places in 1979.

The house was built in 1862 by Orion Clemens, a lawyer who served as the first Secretary of the Nevada Territory.

The house often hosted Orion's younger brother Samuel Clemens, better known as Mark Twain.

This article about a property in Nevada on the National Register of Historic Places is a stub.