It is significant for its association with the economically important role of the V&T railroad historically in Carson City following discovery of the Comstock Lode mine in 1859.

It was created to allow massive movement of gold and silver ore from the Comstock Lode to mills along the Carson River.

The V&T's yards and Engine House were located just east of the depot along Washington Street.

In 1906, the V&T expanded the route South from the Carson City depot to Minden to serve agricultural interests at the farms and ranches in the area.

In 1938, with the mining all but nonexistent, and competition from the newly created United States Highway System, the V&T had to tear up the track from Virginia City to Mound House, which still had a connection with the Carson and Colorado Railroad.