Oriskany Creek is a 33-mile-long (53 km)[2] river in New York, United States.

Oriskany Creek is wide and shallow, affording passage to only canoes, and that for only part of its length.

The Oneida village of Oriskany was located near the mouth of the creek, by the Mohawk River.

During the American Revolutionary War, part of the Battle of Oriskany was fought in a swampy, steep ravine, near the mouth of the river.

When settlers arrived, the creek became the power source of many mills along its course.