It is situated near the right bank of the river Evros, which forms the border with Bulgaria here.

On the other side of the Evros, 6 km to the north, lies the Bulgarian town Svilengrad.

Nearby villages in Greece are Ptelea to its southeast and Petrota to its southwest.

In 1371 Ormenio was the site of the Battle of Maritsa in which the Serb army under Ivan Uglesha and his brother Vukashin was decisively defeated by the Ottomans.

Ormenio had a railway station on the line from Didymoteicho to Harmanli in Bulgaria.