The diocesan chancery is located in South Canaan Township, Pennsylvania.

The diocese is grouped geographically into three deaneries, each consisting of a number of parishes.

Each deanery is headed by a parish priest, known as a dean.

The deans coordinate activities in their area's parishes, and report to the diocesan bishop.

The current deaneries of the Diocese of Eastern Pennsylvania are: The diocese has several active departments, including A Diocesan Revitalization committee has also been created for the purpose of revitalizing all parishes within the diocese, to foster spiritual growth and address the various challenges facing the Diocese today.