The orthodox stance has two major advantages for all practitioners: its ubiquity and its placement of the lead hand and foot closer to the right side of the opponent.
While this stance is predominantly associated with right-handed fighters, there is a notable contingent of left-handed orthodox fighters, including such prominent figures as Oscar De La Hoya, Sonny Liston, Miguel Angel Cotto, Gerry Cooney, Mike Tyson, Sean Strickland, Michael Bisping, Renan Barao, and Marco Antonio Barrera.
Some famous boxers who use the southpaw stance are Marvelous Marvin Hagler, Victor Ortiz, Sultan Ibragimov, Naseem Hamed, Joe Calzaghe, Manny Pacquiao, and Lucian Bute.
Notably, many fighters such as Francisco Palacios, Andre Ward, Jon Jones, and Terence Crawford normally fight as orthodox, but occasionally switch to a southpaw stance.
While southpaw is generally associated with left-handed fighters, there are some right-handed individuals who favor the stance over orthodox, such as Vasiliy Lomachenko, Oleksandr Usyk, Shakur Stevenson, and Nate Diaz.