In its infancy, osCommerce was referred to by Ponce de Leon as "a side thing" and "an example research study".

In 2021, the Holbi Group purchased osCommerce from Ponce De Leon and announced their intention to create 4.x.

Its release was eventually scheduled for March 2022, however it was delayed due to the Russian invasion of Ukraine.

[11] It has also spawned a number of forks, such as Zen Cart, xt:Commerce, oscMAX and Phoenix.

[12] In August 2011 three vulnerabilities in version 2.2 of the osCommerce system were exploited, allowing the addition of an iframe and JavaScript code to infect visitors to websites.