[2] The county was organized January 29, 1841, and named from the Osage River.

[3] Osage County is part of the Jefferson City, MO Metropolitan Statistical Area.

Its geography and the founding of Westphalia Vineyards links it to the Missouri Rhineland, extending along the Missouri River valley to the western edges of the St. Louis Metropolitan Area.

23.80% of all households were made up of individuals, and 10.80% had someone living alone who was 65 years of age or older.

The Republican Party mostly controls politics at the local level in Osage County.

Donald J. Trump received more votes, a total of 1,316, than any candidate from either party in Osage County during the 2016 presidential primary.