The race takes place in the city and passes prominent landmarks such as Osaka Castle.

The course was altered in 2011 to allow for faster times by cutting out a number of hilly sections near Osaka Castle.

[1] The finish line of the race is at Nagai Stadium, which was the host venue for the 2007 World Championships in Athletics.

[3][4] The Japanese rock group The Alfee provided a new theme song for Kansai TV's broadcast of the event every year for 31 consecutive years from 1987 until 2018, when the broadcaster announced they would no longer use themes.

All her results from 26 August 2011 to 30 September 2015, including victories in the 2013, 2014 and 2015 editions of the Osaka International Ladies Marathon, were annulled.