The promotion was founded by Super Delfin on March 4, 1999 following his departure from Michinoku Pro Wrestling, and has been operated by Zeus since July 2021.

In January 1999, Super Delfin announced that due to disagreements with The Great Sasuke regarding the direction of Michinoku Pro Wrestling, he would be leaving the promotion alongside several wrestlers and backstage personnel.

On March 1, 2014, Osaka Pro announced that it would fold on April 20, 2014 due to financial difficulties, after which all of its wrestlers would become freelancers.

[2] Osaka Pro later announced that the promotion would continue under new president Yuji Sakagami and wrestlers Kuishinbo Kamen and Takoyakida.

The new Osaka Pro Wrestling lost many of the old one's key wrestlers as well as their home base of Nasci Hall Umeda, forcing them to employ a new tour format.