The group originated in the Vomero neighborhood of Naples with the union of Lino Vairetti (voice), Danilo Rustici (guitar), Massimo Guarino (drums), Lello Brandi (bass), from the first line-up of the band Città Frontale, and Elio D'Anna (flute and sax), former member of the Showmen.

Their following album Palepoli (1973) is regarded as one of the finest hours of the Italian progressive rock movement,[1] characterized by a wild composition fantasy which mixes Neapolitan and Mediterranean sounds with modern progressive rock elements, such as the extensive use of electric guitar and mellotron.

The band disbanded but reformed in 1977 without D'Anna, who was replaced by keyboardist Fabrizio D'Angelo, while the bass role was taken up by Enzo Petrone.

The Osanna reformed in 1999, releasing the LP Taka boom the following year, including old successes and some new songs.

Later, with David Jackson and Gianni Leone, the band contributed eight tracks to the live boxed set Prog exhibition.