Oseadeeyo Kwasi Akuffo III (born Odehye Kwadwo Kesse Antwi; 24 February 1986) is a Ghanaian traditional ruler who is the Omanhene (or paramount chief) of the Akuapem traditional area (Okuapeman) in Ghana.

Akuffo was born Odehye Kwadwo Kesse on 24 February 1986 to Alex Antwi, a royal of the Agona clan in Akroso-Ntonaboma and Cynthia Agyemang, also a royal, from the Sakyiabia family in Akropong Akuapem (both in the Eastern Region).

[3] Akuffo attended Presbyterian Boys' Secondary School and proceeded to the Westchester Community College in Valhalla where he earned an associate degree.

He furthered his education at the Mercy College where he received a Bachelor of Science degree in Business Administration, with a specialization in Management.

In 2015, he again enrolled at Mercy College for a master's degree in Human Resource Management but in 2016 was compelled to return to Ghana after the demise of his uncle and predecessor Oseadeeyo Nana Addo Dankwa.