Osman Mohammud Dufle (Somali: Cismaan Maxamed Dufle, Arabic: عثمان محمود ضوفلآ) is a Somali physician and politician.

He previously served as a Minister of Health in the Transitional National Government of Somalia.

[1] He was also one of the founders of the Joint Medical Committee, a professional organization for doctors in the country.

He served as a volunteer at the Keysaney Hospital in Mogadishu.

In June 2014, he was nominated for a Nobel Prize in recognition of his humanitarian work.