Osmer Beech Wheeler (February 14, 1809 Bethel, Fairfield County, Connecticut – August 11, 1906 Middletown, Orange County, New York) was an American politician from New York.
Osmer B. Wheeler became a tanner, and in 1830 removed to Greene County, New York where he worked as a foreman at Zadock Pratt's tannery.
About 1838, he removed to Sullivan County, New York, established there his own tannery in a place which lies now in the Town of Forestburgh.
Wheeler was a Know Nothing member of the New York State Senate (9th D.) in 1858 and 1859.
Osmer died on August 11, 1906 Middletown, Orange County, New York.