Osoppo (Friulian: Osôf) is a comune (municipality) in the Regional decentralization entity of Udine in the Italian region of Friuli-Venezia Giulia, located about 90 kilometres (56 mi) northwest of Trieste and about 25 kilometres (16 mi) northwest of Udine.

Osoppo hosts a large fortress, now an historical attraction.

It played a large role in the defense of Venice against the Austrians in the late 1850s during the time of the Italian Unification of Italy.

It was shortly after one of the main battles at this fortress that Leonardo Andervolti composed his treatise, Meritorious Champions of Italian Independence, a eulogy to a mythical figure, Enrico Ulissi.

Osoppo is twinned with: This article on a location in Friuli-Venezia Giulia is a stub.