Oss (Dutch: [ɔs] ⓘ) is a municipality and a city in the southern Netherlands, in the province of North Brabant, situated between Nijmegen and 's-Hertogenbosch.

Oss was granted city rights in 1399 by Hertogin (Duchess) Johanna van Brabant.

Present-day Oss has several chemical and pharmaceutical industries like Merck & Co. (previously Schering-Plough, Organon and Diosynth).

Oss is also host to the professional football team TOP Oss, and is the birthplace of former Manchester United and Real Madrid star Ruud van Nistelrooy, although he did not play for the local side, but for rivals FC Den Bosch.

The municipality covered an area of 42.68 km² and also included villages: Demen, Dennenburg, Deursen, Dieden, Herpen, Huisseling, Keent, Koolwijk, Neerlangel, Neerloon, Overlangel.