[1] The radiographic appearance of osteopoikilosis on an X-ray is characterized by a pattern of numerous white densities of similar size spread throughout all the bones.

It must be differentiated from blastic metastasis, which can also present radiographically as white densities interspersed throughout bone.

Blastic metastasis tends to present with larger and more irregular densities in less of a uniform pattern.

The distribution is variable, though it does not tend to affect the ribs, spine, or skull.

[2] Men and women are affected in equal number,[3] reflecting the fact that osteopoikilosis attacks indiscriminately.