[2] Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins.

[2] The 24 tandem ankyrin repeats are responsible for the recognition of a wide range of membrane proteins.

These two properties in combination give rise to large repertoire of proteins ankyrin can recognise.

Individuals with reduced or defective ankyrinR have a form of hemolytic anemia termed hereditary spherocytosis.

[6] It has been suggested that Ankyrin 1 interacts with KAHRP (shown via selective pull-downs, SPR and ELISA).